2024
48) H. Alirzayeva, R. Loureiro, S. Koyuncu, F. Hommen, Y. Nabawi, W.H. Zhang, T.T.P. Dao, M. Wehrmann, H.J. Lee, and D. Vilchez (2024). ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes. Cell Reports 43:114626.
47) X. Li, I. Hernandez, S. Koyuncu, B. Kis, M. Häggblad, L. Lidemalm, A.A. Abbas, S. Bendegúz, A. Göblös, L. Brautigam, J.J. Lucas, J. Carreras-Puigvert, D. Hühn, K. Pircs, D. Vilchez, and O. Fernandez-Capetillo (2024). The anti-leprosy drug clofazimine reduces polyQ toxicity through activation of PPARγ. EBioMedicine 103:105124.
2023
46) E. Llamas, S. Koyuncu, H.J. Lee, M. Wehrmann, R. Gutierrez-Garcia, N. Dunken, N. Charura, S. Torres-Montilla, E. Schlimgen, A.M. Mandel, E. Boelen-Theile, J. Grossbach, P. Wagle, B. Schermer, T. Benzing, A. Beyer, P. Pulido, M. Rodriguez-Concepcion, A. Zuccaro, and D. Vilchez (2023). In planta expression of human polyQ-expanded huntingtin fragment reveals mechanisms to prevent disease-related protein aggregation. Nature Aging 3: 1345-1357 (cover). https://doi.org/10.1038/s43587-023-00502-1
45) H.J. Lee, H. Alirzayeva, S. Koyuncu, A. Khodakarami, A. Noormohammadi, and D. Vilchez (2023). Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes. Nature Aging 3: 546-566. https://www.nature.com/articles/s43587-023-00383-4
44) M. Wehrmann and D. Vilchez (2023). The emerging roles and therapeutic implications of bacterial and parasitic deubiquitinating enzymes. Frontiers in Immunology. doi: 10.3389/fimmu.2023.1303072
43) R. Gutierrez-Garcia, S. Koyuncu, F. Hommen, S. Bilican, H.J. Lee, A. Fatima, and D. Vilchez (2023). G3BP1-dependent mechanism suppressing protein aggregation in Huntington’s models and its demise upon stress granule assembly. Human Molecular Genetics 32: 1607-1621. https://doi.org/10.1093/hmg/ddac30
42) F. Kohle, R. Ackfeld, F. Hommen, I. Klein, M.K.R. Svačina, C. Schneider, G.R. Fink, M. Barham, D. Vilchez, H.C. Lehmann (2023). Kinesin-5 inhibition improves neural regeneration in experimental autoimmune neuritis. Journal of Neuroinflammation 20: 139
41) K. Voelkl, S. Gutiérrez-Ángel, S. Keeling, S. Koyuncu, M. da Silva Padilha, D. Feigenbutz, T. Arzberger, D. Vilchez, R. Klein, and I. Dudanova (2023). Neuroprotective effects of hepatoma-derived growth factor in models of Huntington's disease. Life Science Alliance 6:e202302018.
40) N. Ruiz-Solaní, J. Salguero-Linares, L. Armengot, J. Santos, I. Pallarès, K.P. van Midden, U.J. Phukkan, S. Koyuncu, J. Borràs-Bisa, L. Li, C. Popa, F. Eisele, A.M. Eisele-Bürger, S.M. Hill, E. Gutiérrez-Beltrán, T. Nyström, V. Valls, E. Llamas, D. Vilchez, M. Klemenčič, S. Ventura, and N.S. Coll (2023). Arabidopsis metacaspase MC1 localizes in stress granules, clears protein aggregates and delays senescence. Plant Cell 35: 3325-3344
39) A. Johns, R. Higuchi-Sanabria#, M.A. Thorwald#, and D. Vilchez# (2023). A tale of two pathways: regulation of proteostasis by UPRmt and MDPs. Current Opinion in Neurobiology. 78: 102673. #These authors share senior authorship.
2022
38) W.H. Zhang, S. Koyuncu#, and D. Vilchez#. Insights into the links between proteostasis and aging from C. elegans. Frontiers in Aging doi: 10.3389/fragi.2022.854157 #These authors share senior authorship.
37) V. Balaji, L. Müller, R. Lorenz, E. Kevei, W.H. Zhang, U. Santiago, J. Gebauer, E. Llamas, D. Vilchez, C.J. Camacho, W. Pokrzywa, and T. Hoppe. A dimer-monomer switch controls CHIP-dependent substrate ubiquitylation and processing. Molecular Cell 82: 3239-3254.
2021
36) S. Koyuncu, R. Loureiro, H.J. Lee, P. Wagle, M. Krueger and D. Vilchez. Rewiring of the ubiquitinated proteome determines ageing in C. elegans. Nature 596: 285-290.
35) E. Llamas, S. Torres-Montilla, H.J. Lee, M.V. Barja, E. Schlimgen, N. Dunken, P. Wagle, W. Werr, A. Zuccaro, M. Rodriguez-Concepcion and D. Vilchez (2021). The intrinsic chaperone network of Arabidopsis stem cells confers protection against proteotoxic stress. Aging Cell 20: e13446.
34) G. Calculli, H.J. Lee, K. Shen, U. Pham, M. Herholz, A. Trifunovic, A. Dillin and D. Vilchez. Systemic regulation of mitochondria by germline proteostasis prevents protein aggregation in the soma of C. elegans. Science Advances 7: eabg3012.
33) F. Hommen, S. Bilican and D. Vilchez. Protein clearance strategies for disease intervention. Journal of Neural Transmission 129: 141-172
32) Sarroca, A. Gatius, E. Rodríguez-Farré, D. Vilchez, M. Pallàs, C. Griñán-Ferré, C. Sanfeliu and R. Corpas. Resveratrol confers neuroprotection against high-fat diet in a mouse model of Alzheimer's disease. The Journal of Nutritional Biochemistry 89: 108569.
2020
31) E. Llamas, H. Alirzayeva, R. Loureiro and D. Vilchez. The intrinsic proteostasis network of stem cells. Current Opinion in Cell Biology 67: 46-55.
30) A. Fatima, D. Irmak, A. Noormohammadi, M.M. Rinschen, A. Das, O. Leidecker, C. Schindler, V. Sánchez-Gaya, P. Wagle, W. Pokrzywa, T. Hoppe, A. Rada-Iglesias and D. Vilchez. The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells. Communications Biology 3: 262.
29) A. Thiruvalluvan, E. P. de Mattos, J.F. Brunsting, R. Bakels, D. Serlidaki, L. Barazzuol, P. Conforti, A. Fatima, S. Koyuncu, E. Cattaneo, D. Vilchez, S. Bergink, E. HWG Boddeke, S. Copray and H.H. Kampinga. DNAJB6, a key factor in neuronal sensitivity to amyloidogenesis. Molecular Cell. 78:346-358.
28) I. Saez, J. Gerbracht, S. Koyuncu, H.J. Lee, M. Horn, V. Kroef, M. Denzel, C. Dieterich, N. Gehring and D. Vilchez. The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells. FEBS Letters 594:175-188.
2019
27) C. Kumsta, J.T. Chang, R. Lee, E.P. Tan, Y. Yang, R. Loureiro, E.H. Choy, S.H.Y. Lim, I. Saez, A. Springhorn, T. Hoppe, D. Vilchez and M. Hansen. The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy. Nature Communications 10: 5628.
26) H.J. Lee, A. Noormohammadi, S. Koyuncu, G. Calculli, M. Simic, M. Herholz, A. Trifunovic and D. Vilchez. Prostaglandin signals from adult germline stem cells delay somatic ageing of Caenorhabditis elegans. Nature Metabolism 1:790-810 (cover).
25) A. Fatima, R. Gutierrez-Garcia and D. Vilchez. Induced pluripotent stem cells from Huntington's disease patients: a promising approach to define and correct disease-related alterations. Neural Regeneration Research 14:769-770.
2018
24) D. Irmak, A. Fatima, R. Gutierrez-Garcia, M. Rinschen, P. Wagle, J. Altmüller, L. Arrigoni, B. Hummel, C. Klein, C.K. Frese, R. Sawarkar, A. Rada-Iglesias and D. Vilchez. Mechanism suppressing H3K9 trimethylation in pluripotent stem cells and its demise by polyQ-expanded huntingtin mutations. Human Molecular Genetics 27:4117-4134.
23) S. Koyuncu, I. Saez, H.J. Lee, R. Gutierrez-Garcia, W. Pokrzywa, A. Fatima, T. Hoppe and D. Vilchez. The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients. Nature Communications 9: 2886.
22) I. Gonçalves, J. Brecht, M. Thelen, W. Rehorst, M. Peters, H.J. Lee, S. Motameny, L. Torres-Benito, D. Ebrahimi-Fakhari, N. Kononenko, J. Altmüller, D. Vilchez, M. Sahin, B. Wirth and M.J. Kye. Neuronal activity regulates DROSHA via autophagy in Spinal Muscular Atrophy. Scientific Reports 8: 7907.
21) I. Saez, S. Koyuncu, R. Gutierrez-Garcia, C. Dieterich and D. Vilchez. Insights into the ubiquitin-proteasome system of human embryonic stem cells. Scientific Reports 8: 4092.
20) A. Noormohammadi, G. Calculli, R. Gutierrez-Garcia, A. Khodokarami, S. Koyuncu and D. Vilchez. Mechanisms of protein homeostasis (proteostasis) mantain stem cell identity in mammalian pluripotent stem cells. Cellular and Molecular Life Sciences 75: 275-90.
2017
19) H.J. Lee, D. Bartsch, C. Xiao, S. Guerrero, G. Ahuja, C. Schindler, J.M. Moresco, J.R. Yates III, F. Gebauer, H. Bazzi, C. Dieterich, L. Kurian and D. Vilchez. A post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells. Nature Communications 8: 1456.
18) S. Koyuncu, A. Fatima, R. Gutierrez-Garcia and D. Vilchez. Proteostasis of Huntingtin in Health and Disease. International Journal of Molecular Sciences 18(7): 1568 doi:10.3390/ijms18071568.
17) H.J. Lee, R. Gutierrez-Garcia and D. Vilchez. Embryonic stem cells: a novel paradigm to study proteostasis? FEBS Journal 284: 391-98.
2016
16) A. Noormohammadi, A. Khodokarami, R. Gutierrez-Garcia, H.J. Lee, S. Koyuncu, T. Konig, C. Schindler, I. Saez, A. Fatima, C. Dieterich and D. Vilchez. Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan. Nature Communications 7: 13649.
15) M.M. Rinschen, P. Bharill, X. Wu, P. Kohli, M.J. Reinert, O. Kretz, I. Saez, B. Shermer, M. Hohne, M.P. Bartram, S. Aravamudhan, R.R. Brooks, D. Vilchez, T.B. Huber, R.U. Muller, M. Krueger and T. Benzing. The ubiquitin ligase Ubr4 controls stability of podocin/MEC2 supercomplexes. Human Molecular Genetics 25: 1328-44.
2015
14) S. Koyuncu, D. Irmak, I. Saez and D. Vilchez . Defining the general principles of stem cell aging: lessons from organismal models. Current Stem Cell Reports 1(3): 162-169.
13) A. Khodakarami, I. Saez, J. Mels and D. Vilchez . Mediation of organismal aging and somatic proteostasis by the germline. Frontiers in Molecular Biosciences 2(3): 1-7.
12) I. Saez and D. Vilchez (2015). Protein clearance mechanisms and their demise in age-related diseases. AIMS Molecular Science 2(1): 1-21.
2014
11) D. Vilchez, I. Saez and A. Dillin. The role of protein clearance mechanisms in organismal ageing and age-related diseases. Nature Communications 5: 5659.
10) I. Saez and D. Vilchez. The mechanistic links between proteasome activity, aging and age-related diseases. Current Genomics 15(1): 38-51.
9) Vilchez, D.*, Simic, M.*. and Dillin, A. Proteostasis and aging of stem cells. Trends in Cell Biology. 24(3): 161-170. *These authors contributed equally to this work
2013
8) Vilchez, D., Boyer, L., Lutz, M., Merkwirth, C., Morantte, I., Tse C., Spencer, B., Page, L., Masliah, E., Berggren, W.T., Gage, F.H. and Dillin, A. FOXO4 is necessary for neural differentiation of human embryonic stem cell. Aging Cell 12 (3): 518-522.
2012
7) Vilchez, D., Boyer, L., Morantte, I., Lutz, M., Merkwirth, C., Joyce D., Spencer, B., Page, L., Masliah, E., Berggren, W.T., Gage, F.H. and Dillin, A. Increased proteasome activity in human embryonic stem cells is regulated by PSMD11. Nature 489 (7415): 304-308.
6) Vilchez, D., Morantte, I., Liu, Z., Douglas, P.M., Merkwirth, C., Rodrigues, A.P., Manning, G. and Dillin, A. RPN-6 determines C. elegans longevity under proteotoxic stress conditions. Nature 489 (7415): 263-268.
2008
5) Solaz-Fuster, M.C., Gimeno-Alcañiz, J.V., Ros, S., Fernández-Sánchez, M.E., Garcia-Fojeda, B., Criado-García, O., Vilchez, D., Domínguez, J., García-Rocha, M., Sánchez-Piris, M., Aguado, C., Knecht, E., Serratosa, J., Guinovart, J.J., Sanz, P. and Rodríguez de Córdoba, S. Regulation of glycogen synthesis by the laforin-malin complex is modulated by the AMP-activated protein kinase pathway. Human Molecular Genetics 17(5):667-78
2007
4) Vilchez, D., Ros, S., Pujadas, L., Cifuentes, D., Vallès, J., Garcia-Fojeda, B., Criado-García, O., Fernández-Sánchez, E., Medraño-Fernández, M., Domínguez, J., García-Rocha, M., Soriano, E., Rodríguez de Córdoba, S. and Guinovart, J.J. Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy. Nature Neuroscience 10(11):1407-13.
2006
3) Sebastià, J., Pertusa, M., Vilchez, D., Planas, A.M., Verbeek, R., Rodríguez-Farré, E., Cristòfol, R. and Sanfeliu, C. Carboxyl-terminal fragment of amyloid precursor protein and hydrogen peroxide induce neuronal cell death through different pathways. Journal of Neural Transmission 113(12):1837-1845.
2004
2) Sebastià, J., Cristòfol, R.M., Pertusa, M., Vilchez, D., Torán, N., Barambio, S., Rodríguez-Farré, E. and Sanfeliu, C. Down’s syndrome astrocytes have greater antioxidant capacity than euploid astrocytes. European Journal of Neuroscience 20(9): 2355-2366.
1) Cristòfol, R.M., Gassó, S., Vilchez, D., Pertusa, M., Rodríguez-Farré, E. and Sanfeliu, C. Neurotoxic effects of trimethyltin and triethyltin on human fetal neuron and astrocyte cultures: A comparative study with rat neuronal cultures and human cell lines. Toxicology Letters 152(1): 35-46.
Books
Vilchez, D., Rodríguez de Córdoba, S. and Guinovart, J.J. (2009). Enfermedad de Lafora: epilepsia y regulación del metabolismo del glucógeno por laforina y malina in Avances en Neurociencia: Neurotransmisores y Patologías nerviosas (Monografías de la Real Academia de Farmacia, Monografía XXV: 315-343, Real Academia Nacional de Farmacia, Madrid)
Patents
Vilchez, D. & Dillin, A. “Modulators of Proteasome Activity” US Patent 20,130,065,834
